MAIN RECENT PUBLICATIONS
2025
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de Broucker C, Paradis V, Botero ML, Albuquerque M, Payancé A, Plessier A, Elkrief L, Durand F, Hillaire S, Zafar PE, Garcia Pagan JC, Rautou PE Liver biopsy quality criteria to exclude cirrhosis in case of suspicion of porto-sinusoidal vascular disorder (PSVD) JHEP Reports. 2025 |
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European Association for the Study of the Liver EASL Clinical Practice Guidelines on vascular diseases of the liver Journal of Hepatology. 2025 |
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Riescher-Tuczkiewicz A, Loyau S, Venisse L, Tanguy M, Wawrzyniak A, De Raucourt E, Biquard L, Payancé A, Bissonnette J, Durand F, Arocas V, Bouton MC, Boulaftali Y, Rautou PE Platelet protease nexin-1 limits fibrinolysis in patients with cirrhosis JHEP Reports. 2025 |
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Rautou PE, Lisman T, Hernandez-Gea V, Ripoll C, EASL-Post-Graduate EASL-Post-Graduate course Report: Vascular Biology in Chronic Liver Disease and Clinical Management Implications JHEP Reports. 2025 |
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Riescher-Tuczkiewicz A and Rautou PE. Prediction and prevention of post-procedural bleedings in patients with cirrhosis Clinical and Molecular Hepatology. 2025 |
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Rautou PE* & Chotkoe S*, Biquard L, Wettstein G, Van der Graaff D, Liu Y,
De Man J, Casteleyn C, Thys S, De Vos WH, Bedossa P, Cooreman MP, Baudin M, Abitbol JL, Huot-
Marchand P, Dzen L, Albuquerque M, Broqua P, Junien JL, Vonghia L, Abdelmalek MF, Kwanten WJ #,
Paradis V #, Francque SM #,
Altered liver sinusoidal endothelial cells in MASLD and their evolution following lanifibranor treatment
JHEP Reports. 2025
* Co-first authors
# Shared senior authors
2024
Sidali S* & Spaes Y* , El Husseini K, Goria O, Mallet V, Poujol-Robert A, Gervais
A, Lannes A, Thabut D, Nousbaum JB, Isabelle HO, Costentin C, Heurgué A, Houssel-Debry P, Hillaire
S, Ganne-Carrié N, Drilhon N, Valainathan SR, Moga L, Tanguy M, Marcault E, Plessier A, Durand F,
Raevens S, Paradis V, Cachier A, Elkrief L, Rautou PE,
Hepatopulmonary syndrome in patients with porto-sinusoidal vascular disorder: characteristics and outcome.
JHEP Report. 2024
*Co-first authors
M. Magaz* & H. Giudicelli-Lett*, J. G. Abraldes, O. Nicoara-Farcau, F. Turon, N. Rajoriya, A. Goel, K. Raymenants, S. Hillaire, L. Téllez, L. Elkrief, B. Procopet, L. Orts, F. Nery, A. Shukla, H. Larrue, H. Degroote, V. Aguilera, E. Llop, L. Turco, F. Indulti, S. Gioia, G. Tosetti, N. Bitto, C. Becchetti, E. Alvarado, C. Roig, Raquel Diaz, M. Praktiknjo, AL. Konicek, P. Olivas, J. Ignacio Fortea, H. Masnou, Á. Puente, A. Ardèvol, C. A. Navascués, M. Romero-Gutiérrez, B. Scheiner, G. Semmler, M. Mandorfer, F. Damião, A.Baiges, A. Ojeda, M. Simón-Talero, C. González-Alayón, A. Díaz, Á. García-Criado, A.De Gottardi, M. Hernández-Guerra, J. Genescà, N. Drilhon, C. N. Ferreira, T. Reiberger, M. Rodríguez, R. M. Morillas, J. Crespo, J. Trebicka, R. Bañares, C. Villanueva, A. Berzigotti, M. Primignani, V. La Mura, O. Riggio, F. Schepis, X. Verhelst, J.Luis Calleja, C. Bureau, A. Albillos, F. Nevens, V. Hernández-Gea, D. Tripathi, PE. Rautou$ & J. C. García-Pagán$
Porto-sinusoidal vascular liver disorder with portal hypertension: Natural history and long-term outcome
Journal of hepatology. 2024
*Co-first authors
$ Shared senior authors
Ciriaci N., Bertin L., Rautou PE.
Genetic predisposition to porto-sinusoidal vascular disorder
Hepatology. 2024
Elkrief L., Hernandez-Gea V., Senzolo M., Albillos A., Baiges A., Berzigotti A., Christophe Bureau C., Darwish Murad S., De Gottardi A., Durand F., Garcia-Pagan J-C., Lisman T., Mandorfer M., McLin V., Moga M., Nery F., Northup P., Nuzzo A., Paradis V., Patch D., Payancé A., Plaforet V., Plessier A., Poisson J., Roberts L., Salem R., Sarin S., Shukla A., Toso C., Tripathi D., Valla D., Ronot M., Rautou PE., on behalf of ERN RARE-LIVER and VALDIG, an EASL consortium
Portal vein thrombosis: diagnosis, management, and endpoints for future clinical studies
The Lancet Gastroenterology & Hepatology. 2024
Moga L, Paradis V, Ferreira-Silva J, Gudavalli K, Indulti F, Dajti E, Nicoara-Farcau O, Tosetti G, Antonenko A, Fodor A, Vidal-González J, Turco L, Capinha F, Elkrief L, Monllor-Nunell T, Goria O, Balcar L, Lannes A, Mallet V, Poujol-Robert A, Thabut D, Houssel-Debry P, Wong YJ, Ronot M, Vilgrain V, Rampally SP, Payancé A, Castera L, Reiberger T, Ferrusquía-Acosta J, Noronha Ferreira C, Vitale G, Simon-Talero M, Procopet B, Berzigotti A, Caccia R, Turon F, Schepis F, Ravaioli F, Colecchia A, Valsan A, Macedo G, Plessier A, Rautou PE; ERN RARE-LIVER; a study of VALDIG, an EASL consortium.
Performance of spleen stiffness measurement to rule out high-risk varices in patients with porto-sinusoidal vascular disorder
Hepatology. 2024
Palomino-Echeverria S., Huergo E., Ortega-Legarreta A., Uson Raposo E. M., Aguilar F., de la Peña-Ramirez C., López-Vicario C., Alessandria C., Laleman W., Queiroz Farias A., Moreau R., Fernandez J., Arroyo V., Caraceni P., Lagani V., Sánchez-Garrido C., Clària J., Tegner J., Trebicka J., Kiani N. A., Planell N., Rautou PE & Gomez-Cabrero D.
A robust clustering strategy for stratification unveils unique patient subgroups in acutely decompensated cirrhosis
Journal of Translational Medicine. 2024
Ciriaci N., Rautou PE. & Poisson J.
Loss of fenestrae in liver sinusoidal endothelial cells contributes to MASLD
Nature Cardiovascular Reasearch. 2024
Valainathan S.R, Xie Q., Arroyo V., Rautou PE
Prognosis algorithms for acute decompensation of cirrhosis and ACLF
Liver International. 2024
Giabicani M., Joly P., Sigaut S., Timsit C., Devauchelle P., Dondero F., Durand F., Froissant P.A., Lamamri M., Payancé A., Restoux A., Roux O., Thibault-Sogorb T., Ram Valainathan S, Lesurtel M., Rautou PE, Weiss E.
Predictive Role of Hepatic Venous Pressure Gradient in Bleeding Events Among Cirrhotic Patients Undergoing Orthotopic Liver Transplantation
JHEP Reports. 2024
2023
Riescher-Tuczkiewicz A., Caldwell S.H., Kamath P. S., Villa E., Rautou PE
Expert opinion on bleeding risk from invasible procedures in cirrhosis
JHEP Reports. 2023
Hammoutène A, Tanguy M, Calmels M, Pravisani R, Albuquerque M., Casteleyn C, Slimani L, Sadoine J, Boulanger CM, Paradis V, Gilgenkrantz H, Rautou PE
Endothelial autophagy is not required for liver regeneration after partial hepatectomy in mice with fatty liver
Liver International. 2023
Elkrief L, Ganne-Carrié N, Manceau H, Tanguy M, Valainathan SR, Riescher-Tuczkiewicz A, Biquard L, Barget N, Chaffaut C, Louvet A, Paradis V, Ziol M, Bæk R, Jørgensen MM, Van Niel G, Coly PM, Hammoutène A, Dujardin F, Peoc'h K, Poynard T, Chevret S, Rautou PE; CIRRAL group.
Hepatocyte-derived biomarkers predict liver-related events at 2 years in Child-Pugh class A alcohol-related cirrhosis.
J Hepatol. 2023
Rautou PE, Caldwell SH, Villa E.
Bleeding and Thrombotic Complications in Patients with Cirrhosis: A State of the Art Appraisal
Clin Gastroenterol Hepatol. 2023
Elkrief L, Payancé A, Plessier A, d'Alteroche L, Ronot M, Valérie Paradis V, Valla D, Rautou PE
Management of splanchnic vein thrombosis
JHEP Rep. 2023
2022
Gressens S B, Cazals-Hatem D, Lloyd V, Plessier A, Payancé A, Lebrec D Durand F, Socie G, Valla D, Paradis V, Michonneau D, Rautou PE
Hepatic venous pressure gradient in sinusoidal obstruction syndrome: diagnostic value and link with histological lesions
JHEP Rep. 2022
Bissonnette J*, Riescher-Tuczkiewicz A*, Gigante E, Bourdin C, Boudaoud L, Soliman H, Durand F, Ronot M, Valla D, Vilgrain V, de Raucourt E, Rautou PE
Predicting bleeding after liver biopsy using comprehensive clinical and laboratory investigations: A prospective analysis of 302 procedures
JTH. 2022
Al-Rifai R*, Marie Vandestienne M*, Lavillegrand JR, Mirault T, Cornebise J, Poisson J, Laurans L, Esposito B, James C, Mansier O, Hirsch P, Favale F, Braik R, Knosp C, Vilar J, Rizzo G, Zernecke A, Saliba A, Tedgui A, Lacroix M, Arrive L, Mallat Z, Taleb S, Diedisheim M, Cochain C, Rautou PE & Ait-Oufella H
JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm
Nature Communications. 2022
Artru F, Vietti-Violi N, Sempoux C, Barbosa JV , Becce F, Sah N, Marot A, Deltenre P, Moschouri E, Fraga M, Hocquelet A, Duran R, Moradpour D, Rautou PE*, Denys A*.
Portal vein recanalisation alone to treat severe portal hypertension in non-cirrhotic patients with chronic extrahepatic portal vein obstruction
JHEP Rep. 2022
Ram Valainathan S, Sartoris R, Elkrief L, Magaz M, Betancourt F, Pellegrino S, Nivolli A, Dioguardi Burgio M, Flattet Y, Terraz S, Drilhon N, Lazareth M, Herrou J, Bruno O, Payance A, Plessier A, Durand F, Ronot M, Valla D-C, Paradis V, Garcia-Pagan JC, Valérie Vilgrain V, Rautou PE.
Contrast-enhanced CT and liver surface nodularity for the diagnosis of porto-sinusoidal vascular disorder : a case-control study.
Hepatology 2022
De Broucker C, Plessier A , Ollivier-Hourmand I, Dharancy S, Bureau C, Cervoni JP, Sogni P, Goria O, Corcos O, Sartoris R, Ronot M, Vilgrain V , De Raucourt E , Zekrini K , Davy H, Durand F , Payancé A, Fidouh-Houhou N , Yazdanpanah Y, Valla D, Rautou PE .
Multicenter study on recent portal venous system thrombosis associated with cytomegalovirus disease
J Hepatol 2022
2021
Kostallari E, Valainathan S, Biquard L, Shah VH, Rautou PE .
Role of extracellular vesicles in liver diseases and their therapeutic potential
Adv Drug Deliv Rev 2021 Aug
Elkrief L, Lazareth M, Chevret S, Paradis V, Magaz M, Blaise L, Rubbia-Brandt L, Moga L, Durand F, Payancé A, Plessier A, Chaffaut C, Valla D, Malphettes M, Diaz A, Nault JC, Nahon P, Audureau E, Ratziu V, Castera L, Garcia Pagan JC, Ganne-Carrie N, Rautou PE .
Liver stiffness by transient elastography to detect porto-sinusoidal vascular liver disease with potal hypertension
Hepatology 2021 Jul
2020
Hammoutene A, Pierre-Emmanuel Rautou PE.
Role of autophagy in liver sinusoidal endothelial cells in nonalcoholic steatohepatitis
Med Sci (Paris) 2020 Aug-Sep
Thietart S , Pierre-Emmanuel Rautou PE.
Extracellular vesicles as biomarkers in liver diseases: A clinician's point of view.
J Hepatol 2020 Jul
Biquard L , Valla D. , Rautou PE .
No evidence for an increased liver uptake of SARS-CoV-2 in metabolic-associated fatty liver disease.
J Hepatol 2020 May
Poisson J, Tanguy M, Davy H, Camara F, El Mdawar MB1, Kheloufi M, Dagher T, Devue C, Lasselin J, Plessier A, Merchant S, Blanc-Brude O, Souyri M, Mougenot N, Dingli F, Loew D, Hatem SN, James C, Villejal JL, Boulanger CM, Rautou PE.
Erythrocyte-derived microvesicles induce arterial spasms in JAK2V617F myeloproliferative neoplasm.
J Clin Invest 2020 Feb
Erythrocyte-derived microvesicles induce arterial spasms in JAK2V617F myeloproliferative neoplasm.
J Clin Invest 2020 Feb
Hammoutene A, Biquard L, Lasselin J, Kheloufi M, Tanguy M, Vion AC, Mérian J, Colnot N, Loyer X, Tedgui A, Codogno P, Lotersztajn S, Paradis V, Boulanger CM, Rautou PE.
A defect in endothelial autophagy occurs in patients with nonalcoholic steatohepatitis and promotes inflammation and fibrosis.
J Hepatol 2020 Mar.
A defect in endothelial autophagy occurs in patients with nonalcoholic steatohepatitis and promotes inflammation and fibrosis.
J Hepatol 2020 Mar.
2019
Elkrief L, Ferrusquia-Acosta J, Payancé A, Moga L, Tellez L, Praktiknjo M, Procopet B, Farcau O, De Lédinghen V, Yuldashev R, Tabchouri N, Barbier L, Dumortier J, Menahem B, Magaz M, Hernández-Gea V, Albillos A, Trebicka J, Spahr L, De Gottardi A, Plessier A, Valla D, Rubbia-Brandt L, Toso C1, Bureau C, Garcia-Pagan JC, Rautou PE; for VALDIG, an EASL consortium.
Abdominal Surgery in Patients With Idiopathic Noncirrhotic Portal Hypertension: A Multicenter Retrospective Study.
Hepatology. 2019 Sep.
Hammoutene A, Rautou PE.
Role of liver sinusoidal endothelial cells in non-alcoholic fatty liver disease.
J Hepatol. 2019 Jun.
Allaire M, Rautou PE, Codogno P, Lotersztajn S.
Autophagy in liver diseases: Time for translation?
J Hepatol. 2019 May.
Lejealle C, Paradis V, Bruno O, de Raucourt E, Francoz C, Soubrane O, Lebrec D, Bedossa P, Valla D, Mal H, Vilgrain V, Durand F, Rautou PE.
Evidence for an Association Between Intrahepatic Vascular Changes and the Development of Hepatopulmonary Syndrome.
Chest. 2019 Jan.
2018
Andrade F, Shukla A, Bureau C, Senzolo M, D’Alteroche L, Heurgué A, Garcia-Pagan JC, Turon F, Oberti F, Tripathi D, Roux O, Ceccaldi PF, de Raucourt E, Payancé A, Valla D, Plessier A, Rautou PE; VALDIG investigators.
Pregnancy in idiopathic non-cirrhotic portal hypertension: A multicentric study on maternal and fetal management and outcome.
J Hepatol. 2018 Aug 21.
Rautou PE, Busse J, Kheloufi M, Vion AC, Boulaftali Y, Stark K, Boulanger CM.
Endothelial Autophagy Does Not Influence Venous Thrombosis in Mice.
Thromb Haemost. 2018 Jun.
Poisson J, Hilscher MB, Tanguy M, Hammoutene A, Boulanger CM, Villeval JL, Simonetto DA, Valla D, Shah VH, Rautou PE.
Endothelial JAK2V617F does not enhance liver lesions in mice with Budd-Chiari syndrome.
J Hepatol. 2018 May.
Payancé A, Silva-Junior G, Bissonnette J, Tanguy M, Pasquet B, Levi C, Roux O, Nekachtali O, Baiges A, Hernández-Gea V, Laouénan C, Lebrec D, Albuquerque M, Paradis V, Moreau R, Valla D, Durand F, Boulanger CM, Garcia-Pagan JC, Rautou PE.
Hepatocyte microvesicle levels improve prediction of mortality in patients with cirrhosis.
Hepatology. 2018 Mar 30
2017
Vion AC*, Kheloufi M*, Hammoutene A, Poisson J, Lasselin J, Devue C, Pic I, Dupont N, Busse J, Starke K, Lafaurie-Janvore J, Barakatf AI, Loyer X, Souyri M, Viollet B, Julia P, Tedgui A, Codogno P, Boulanger CM*, Rautou PE*.
Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow.
Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8675-E8684
Poisson J, Plessier A, Kiladjian JJ, Turon F, Cassinat B, Andreoli A, De Raucourt E, Goria O, Zekrini K, Bureau C, Lorre F, Cervantes F, Colomer D, Durand F, Garcia-Pagan JC, Casadevall N, Valla DC, Rautou PE*, Marzac C*;
French national network for vascular liver diseases. Selective testing for calreticulin gene mutations in patients with splanchnic vein thrombosis: A prospective cohort study.
J Hepatol. 2017 Sep;67(3):501-507
Bissonnette J, Altamirano J, Devue C, Roux O, Payance A, Lebrec D, Bedossa P, Valla D, Durand F, Ait-Oufella H, Sancho-Bru P, Caballeria J, Boulanger CM, Bataller R, Rautou PE.
A prospective study of the utility of plasma biomarkers to diagnose alcoholic hepatitis.
Hepatology. 2017 Aug;66(2):555-563
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Weiss E*, Rautou PE*, Fasseu M*, Giabicani M, de Chambrun M, Wan J, Minsart C, Gustot T, Couvineau A, Maiwall R, Hurtado-Nedelec M, Pilard N, Lebrec D, Valla D, Durand F, de la Grange P, Monteiro RC, Paugam-Burtz C, Lotersztajn S, Moreau R. Type I interferon signaling in systemic immune cells from patients with alcoholic cirrhosis and its association with outcome. J Hepatol. 2017 May |
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Poisson J, Lemoinne S, Boulanger C, Durand F, Moreau R, Valla D, Rautou PE. Liver sinusoidal endothelial cells: physiology and role in liver diseases. J Hepatol. 2017 Jan;66(1):212-227. |
2016
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Rautou PE, Tatsumi K, Antoniak S, Owens AP 3rd, Sparkenbaugh E, Holle LA, Wolberg AS, Kopec AK, Pawlinski R, Luyendyk JP, Mackman N. Hepatocyte Tissue Factor Contributes to the Hypercoagulable State in a Mouse Model of Chronic Liver Injury. J Hepatol. 2016 Jan;64(1):53-9. |
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Loyer X, Paradis V, Hénique C, Vion AC, Colnot N, Guerin CL, Devue C, On S, Scetbun J, Romain M, Paul JL, Rothenberg ME, Marcellin P, Durand F, Bedossa P, Prip-Buus C, Baugé E, Staels B, Boulanger CM, Tedgui A, Rautou PE. Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARα expression. Gut. 2016 Nov;65(11):1882-1894. |
2014
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Lemoinne S, Thabut D, Housset C, Moreau R, Valla D, Boulanger CM, Rautou PE. The emerging roles of microvesicles in liver diseases. Nat Rev Gastro Hepat. 2014 Jun;11(6):350-61 |
2012
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Rautou PE, Bresson J, Sainte-Marie Y, Vion AC, Paradis V, Renard JM, Devue C, Heymes C, Letteron P, Elkrief L, Lebrec D, Valla D, Tedgui A, Moreau R, Boulanger CM. Abnormal Plasma Microparticles Impair Vasoconstrictor Responses in Patients with Cirrhosis. Gastroenterology. 2012 Jul;143(1):166-76. |