RAUTOU LAB
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Role of vessels in liver diseases


Welcome to the Rautou Lab


The team works on the link between the vessels and liver diseases. We are interested in rare vascular liver diseases (Budd-Chiari syndrome, extrahepatic vein thrombosis and porto-sinusoidal vascular disease), nonalcoholic steatohepatitis and cirrhosis.
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LATEST NEWS

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LAST PUBLICATIONS

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Endothelial autophagy is not required for liver regeneration after partial hepatectomy in mice with fatty liver
Hammoutene A. et al. Liver International. June 2023

Journée recherche FILFOIE 2023
Actualité sur les maladies vasculaires du foie
Pierre-Emmanuel Rautou

LAST PUBLICATIONS




Hepatocyte-derived biomarkers predict liver-related events at 2 years in Child-Pugh class A alcohol-related cirrhosis.
Elkrief L, et al. J Hepatol. 2023




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Bleeding and Thrombotic Complications in Patients with Cirrhosis: A State of the Art Appraisal.
Rautou PE, Caldwell SH, Villa E.
Clin Gastroenterol Hepatol. 2023

EASL STUDIO
EASL-EF CLIF and EU Grants: Exploring novel mechanism and treatment of chronic liver failure

Through widespread multidisciplinary collaboration, consortia and EU grants provide unique opportunities to address critical questions.

  • What opportunities exist for early career scientist?
  • Which elements are essential for success?
  • How have these partnerships contributed to advancements in the field?
Watch this episode of EASL Studio to find out.

  • Prof. Thomas Berg (Moderator)
  • Prof. Rajiv Jalan (Moderator)
  • Prof. Minneke Coenraad (Faculty)
  • Dr Cornelius Engelmann (Faculty)
  • Prof. Pierre-Emmanuel Rautou (Faculty)

LAST PUBLICATIONS

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JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm

Rida Al-Rifai et al. Nat Commun. 2022
Collaboration with Team Ait-Oufella


Hepatic venous pressure gradient in sinusoidal obstruction syndrome: diagnostic value and link with histological lesions

Simon B Gressens. JHEP Rep. 2022
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Management of splanchnic vein thrombosis
Laure Elkrief. JHEP Rep. 2023

EASL STUDIO
YI Choice: how to build consortia and registries

The value of scientific collaboration and data sharing through registries and consortia is unequivocal. But what are the main challenges to building a consortium and how do we overcome them.
Join the faculty as they provide you with a practical, experience-based view of how to build a successful consortium.

  • Dr Marta Afonso (Moderator)
  • Dr Mattias Mandorfer (Moderator)
  • Prof. Jesús Bañales (Faculty)
  • Prof. Rajiv Jalan (Faculty)
  • Prof. Pierre Emmanuel Rautou (Faculty)

DECISION : 7th DECISION Steering Committee Meeting

End of March 2023, the DECISION project marked its 7 steering committee meeting in Pamplona. Two days packed with updates on the overall progress of the project, presented by work package leaders and project members. Lively discussions cemented the project’s path for the next months.
https://twitter.com/i/status/1643223082927022080

EASL STUDIO
YI Choice: Gender equality in academics — reducing the gap

In honour of International Women’s day, this episode of EASL Studio raised awareness about the gender gap in academic research and debating how to improve gender diversity.
  • Dr Johanne Poisson (Moderator)
  • Prof. Eric Trépo (Moderator)
  • Prof. Dina Balabanova (Faculty)
  • Dr ‪Ea Høg Utoft‬ (Faculty)


EASL STUDIO
CIRRHOSIS AND COMPLICATIONS

In this episode of EASL Studio the experts discuss a non-cirrhotic portal vein thrombosis (PVT):
  • What is PVT in the absence of cirrhosis,
  • The role of interventional radiology in the management of portal cavernoma, and
  • An update from the VALDIG portal Vein Thrombosis meeting

Faculty:
  • Prof. Pierre-Emmanuel Rautou (Moderator)
  • Prof. Juan-Carlos Garcia-Pagan (Faculty)
  • Dr Aurélie Plessier (Faculty)
Related article: Rivaroxaban Prophylaxis in Noncirrhotic Portal Vein Thrombosis, Plessier et al. – NEJM Evidence – 2022

Please click here to access the podcast version of this EASL Studio episode.

Congratulations to Louise Biquard for his PhD defense


DECISION
4th General Assembly (GA) meeting in Madrid

The 4th GA meeting of DECISION took place from 19-21 October 2022 in Madrid.

JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm
Rida Al-Rifai - Nature Communications - 2022

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New paper from Hafid Ait-Oufella's team in collaboration with ou team


JAK2V617F
mutation drives vascular resident macrophages toward a pathogenic pheno-type and promotes dissecting aortic aneurysm.



PUMS college= "How to take care of your liver"
with Prof. Pierre-Emmanuel Rautou, Dr. Audrey Payancé and Prof. Laurent Castéra


Predicting bleeding after liver biopsy using comprehensive clinical and laboratory investigations: a prospective analysis of 302 procedures
J. Bissonnette, A. Riescher-Tuczkiewicz, et al.
Journal of thrombosis and haemostasis
. 2022

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- Extensive hemostasis workup does not improve the prediction of liver biopsy-related bleeding
- Pain 2 hours after liver biopsy was associated with the occurrence of biopsy related-bleeding
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Hepatic venous pressure gradient in sinusoidal obstruction syndrome: diagnostic value and link with histological lesions
Simon B. Gressens, et al. J HEP REPORTS 2022

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INTERNATIONAL LIVER CONGRESS
EASL 2022

 EASL Studio : Teatime with Pr. Pierre-Emmanuel Rautou and Dr. johanne Poisson

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Prof Pierre-Emmanuel Rautou moderates a studio session including Prof Pere Gines, Dr Mattias Mandorfer, Prof Debbie Shawcross, and Prof Dominiquer Thabut: great discussions!
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Dr Johanne Poisson has been invited as faculty in EASL studio for the ILC 2022 alongside with Prof. Helena Cortez-Pinto and Prof. Aleksander Krag. This session was moderated by  Prof. Tobias Böttler and Assoc. Prof. Jean-Charles Nault.
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Portal vein recanalisation alone to treat severe portal hypertension in non-cirrhotic patients with chronic extrahepatic portal vein obstruction

Artru F et al; JHEP Rep. 2022

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In patients with technical success, 5-year primary patency was 73%, and was associated with improved muscle mass  and decreased spleen volume at 1 year.
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Prof Pierre-Emmanuel Rautou interviews the chairs of European and American guidelines on coagulation in liver diseases about the interest of anticoagulants in cirrhosis to improve patients' outcome


Contrast-enhanced CT and liver surface nodularity for the diagnosis of porto-sinusoidal vascular disorder: a case-control study
Shantha Ram Valainathan et al. - Hepatology - 2022

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CT-scan to raise suspicion of Porto-Sinusoidal Vascular Disorder (PSVD):
  • Liver Surface Nodularity and size of segment IV have a > 90% specificity for diagnosis of PSVD
  • One more tool to help identify patients with this rare disease
For more details, please read our paper

A new video dedicated to patients, explaining portosinusoidal vascular disorders


Vascular Disorders of the Liver

VALDIG's Guide to Management and Causes

  • A collective book gathering the experience collected during a 15 yr long cooperation between European centers
  • Written by world-leading clinical investigators in the field involved
  • At the interface between highly specialized hepatology and hematology/internal medicine/intensive care/radiology

    Dominique Valla, Juan Carlos Garcia-Pagan, Andrea De Gottardi, Pierre-Emmanuel Rautou

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Multicenter study on recent portal venous system thrombosis associated with cytomegalovirus disease

Chloé De Broucker et al. - J. Hepatol - 2021
CMV disease triggers for portal vein thrombosis :
 => a special link with factor II gene mutation
 =>
do not forget to screen for all risk factors for thrombosis
=>
no impact on recanalisation.
For more details, please read our paper


EASL TAKEWAYS - Cirrhosis and complications

Discover cirrhosis and complications with Professor Didier Samuel, Professor Andrés Cárdenas and Professor Pierre-Emmanuel Rautou

ERN Rare-Liver on-demand Webinar: Porto sinusoidal vascular disease

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Podcast of Prof PE Rautou on porto-sinusoidal vascular disease : link

The International Liver Congress - EASL STUDIO

Prof U Beuers interviews Prof PE Rautou on porto-sinusoidal vascular disease

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​In the March 2021 issue of "Sciences et vie", multiomics are described in great detail. At this occasion, Prof. Pierre-Emmanuel Rautou explains the approach developed in the European project he coordinates, using omics to improve  diagnosis and prognosis of patients with liver diseases :
“C’est pourquoi nous avons lancé avec 20 autres centre européens un vaste projet d’analyse multiomique sur une cohort qui compte déjà 2200 patients.”
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Pierre-Emmanuel Rautou and Valerie Paradis obtained an ARC funding for the project "Endothelial autophagy in liver carcinogenesis related to NonAlcoholic Fatty Liver Disease : Role and potential therapeutic target"


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Congratulations to Louise Biquard for her great award


EASL Digital ILC 2020 Takeaways - Cirrhosis and complications


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The DECISION project coordinated by Prof Rautou
​European researchers seek to reduce the number of patients dying from cirrhosis
Visite the website for more informations => here

Information about COVID pandemic in Hepatology Departments

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New Publication
A defect in endothelial autophagy occurs in patients with alcoholic steatohepatitis and promotes inflammation and fibrosis
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New Publication
Erythrocyte-derived microvesicles induce arterial spasms in JAK2V617F myeloproliferative neoplasm

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Our lab received the "EMERGENCE grant" by the city of Paris for the project  “Predicting Outcome of patients with cirrhosis using circulating extracellular Vesicles”
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Pierre-Emmanuel RAUTOU obtained the ATIP AVENIR funding which allows young scientists to create and lead a team within an established Inserm laboratory in France in January 2019

SPONSORS

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Centre de recherche sur l'inflammation
UMR 1149 Inserm - Université de Paris
ERL CNRS 8252
Faculté de médecine site Bichat
16 rue Henri Huchard F-75018 Paris​
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  • Home
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    • DECISION
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